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Heart HealthHeart and Estrogen/Progestin Replacement Study (HERS)The Heart and Estrogen/Progestin Replacement Study (HERS) found that the use of estrogen plus progestin in postmenopausal women with heart disease did not prevent further heart attacks or death from coronary heart disease (CHD). This occurred despite the positive effect of treatment on lipoproteins: LDL (bad) cholesterol was reduced by 11 percent and HDL (good) cholesterol was increased by 10 percent.The hormone replacement regimen also increased the risk of clots in the veins (deep vein thrombosis) and lungs (pulmonary embolism). HERS involved 2,763 postmenopausal women, average age 67, who were treated for approximately 4 years. Women were randomly assigned to an estrogen/progestin combination or to a placebo. Wyeth-Ayerst Laboratories, the makers of Premarin, funded the study.
Source: The National Heart, Lung and Blood Institute
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